Supervivencia Global en Segunda Línea de Liposarcomas: un objetivo alcanzado

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Eribulin may causeTumour Biology Changes
Classic mitotic effects:
Induction of mitotic crisis and irreversible tumour
cell death1-3
New tumour biology-modifying non-
mitotic effects:
 Remodelling of Tumour Microvasculature 4-6,7
 Tumour EMT Reversal / Cellular
Redifferentiation7,8
 Reduced Aggressiveness and Metastatic
Potential7,8
 Greater tumour visibility by the immune system9
1. Jordan MA, et al. Mol Cancer Ther. 2005;4:1086–1095.
2. Okouneva T, et al. Mol Cancer Ther. 2008;7:2003–2011.
3. Towle MJ, et al. Cancer Res. 2001;61:1013–1021.
4. Funahashi Y, et al. Cancer Sci. 2014;105(10):1334-42.
5. Agoulnik SI, et al. Vasc Cell. 2014;6:3.
6. Ueda S, et al. Br J Cancer. 2016 May 24;114(11):1212-8.
7. Kawano S, et al. Anticancer Res. 2016;36(4):1553-61.
8. Yoshida T, et al. Br J Cancer 2014;110:1497-1505.
9. Goto W, et al., AACR 2016 (abstract 5127).