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For the most of advanced STS, the treatment aim is met by DOXORUBICIN (&OLARATUMAB)
Combination of Anthracyclines plus Ifosfamide has a niche but:
HIGHER RR
HIGHER PFS
The magnitude of the difference in OS is enough for recommending OLARA&DOXO for most
of advanced STS patients
Reference Centers are critical even in Advanced Disease