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© 2017 Eli Lilly and

Tap WD et al.

Lancet

2016;388:488-97 (updated 388:464)

Time (Months)

Olaratumb+Doxorubicin

Independent Review

Assessment

Olaratumab +

Dox

Dox

Patients/Events

66/37

67/34

Median, months

(95% CI)

8.2

(5.5, 9.8)

4.4

(3.1, 7.4)

HR (95% CI)

0.67 (0.40, 1.12)

Stratified p-value

.1208

Investigator

Assessment

Olaratumab +

Dox

Dox

Patients/Events

66/55

67/48

Median, months

(95% CI)

6.6

(4.1, 8.3)

4.1

(2.8, 5.4)

HR (95% CI)

0.67 (0.44, 1.02)

Stratified p-value

.0615

a

a

Met predefined criterion of α=0.20

PFS