19 / 22
BRAF
Subpopulation vs VELOUR ITT
N
OS
PFS
Placebo
Aflibercept
Δ
Placebo
Aflibercept
Δ
VELOUR ITT
1226
12.1
13.5
1.4
4.7
6.9
2.2
Full biomarker population
482
11.4
12.9
1.5
4.3
6.8
2.5
BRAF
wt
446
12.4
(10.7 – 15.1)
13.0
(12.4 –15.9)
0.6
4.5
(4.1 – 5.8)
6.9
(6.2 – 7.7)
2.4
HR (95% CI)
0.84 (0.67 – 1.05)
0.76 (0.61 – 0.94)
BRAF
mutant
36
5.5
(3.5 – 10.6)
10.3
(5.3 – NA)
4.8
2.2
(1.4 – 8.3)
5.5
(2.7 – NA)
3.3
HR (95% CI)
0.42 (0.16 – 1.09)
0.59 (0.22 – 1.58)
Interaction test
0.08
0.29
Retrospective evaluation of a limited dataset can only be hypothesis generating
Wirapati P, et al.
J Clin Oncol.
2017;35 (suppl; abstr 3538).