Tratamiento Dirigido en el Cáncer de Pulmón Microcítico: El Papel de los Marcadores

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Rovalpituzumab Tesirine (Rova-T)
A delta-like protein 3 (DLL3)-targeted antibody-drug conjugate
0
0.0
0.5
1.0
1.5
2.0
2.5
DLL3
DLL1
DLL4
[Ab], (nM)
Absorbance (A450)
Drug-to-Antibody Ratio (DAR) = 2
Cathepsin-B Cleavable Linker
PBD Dimer Toxin
(Pyrrolobenzodiazepine)
Saunders et al., Sci Transl Med 2015
Anti-DLL3 mAb
(SC16)