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DLL3 is a dominant inhibitor of Notch signaling
•
Interacts with and inhibits
Notch1
in
cis
•
Induced by the key neuroendocrine
transcription factor,
ASCL1
•
Normally expressed during
development in the
Golgi
•
Aberrant cell surface
expression
in
>80% SCLC
, on both
cancer stem
and tumor cells
but not normal
adult tissues
•
Not prognostic,
and does
not
predict response to CT
Saunders et al., Sci Transl Med 2015
Tanaka et al
(Lung Cancer 2017)
:
83%, 32% (>50%), = OS