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ALK+
NSCLC is characterised by a rearrangement of the
ALK
gene
EML4 = echinoderm microtubule-associated
protein-like 4
1. Dearden, et al. Ann Oncol 2013
2. Gridelli, et al. Cancer Treat Rev 2014; 3. Hallberg, et al. Nat Rev Cancer 2013
4. Soda, et al. Nature 2007; 5. Rikova, et al. Cell 2007
6. D’Arcangelo, et al. Curr Opin Oncol 2013; 7. Ou, et al. Oncologist 2012
EML4
ALK
EML4
ALK
Rearrangement
Chromosome 2
In
ALK+
NSCLC, the
ALK
gene undergoes a chromosomal rearrangement
1–5
Chromosomal rearrangements lead to the production of ALK fusion proteins.
The most common fusion partner with
ALK
is
EML4,
resulting in the expression
of EML4-ALK fusion proteins
2–7