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ROS-1
ROS-1 occur in 1% NSCLC
Similar to ALK rearrangements more
common: never/light smokers and Adeno
Kinase Domaine of ALK and ROS1 share
77% amino acid identity within ATP binding
sites (main change Val to Leu codon 1180
ALK and codon 2010 ROS)
Those fact give more direct contact with
Crizotinib and then more tightly binds to
ROS1 (0.4 nM to 4.4 nM of ALK)
In ROS1 cell lines Crizotinib blocked cell
viability