¿Importa la secuencia de tratamiento en egfr +?: Factores que deberían ser considerados

Thinking with summing PFSs………………….. OS impact?

EGFR-TKI 1st-2nd generation

T790 +

EGFR-M+ NSCLC

EGFR-TKI 3rd generation

Progression

T790 -

EGFR-TKI

3rd generation

Progression

Chemotherapy

Resistance ?

PFS 1 + PFS 2 + PFS 3 > PFS (?) ; Impact on OS ?

PFS1

PFS3

PFS

>50%

PFS2

Local therapies, TKI maintenance

Symptomatic PD

Local therapies, TKI maintenance?

Chemotherapy

∼

~50%