21 / 30
Most Frequent
Treatment-Related
Adverse Events
Adverse Event
Lenvatinib (n=261)
Placebo (n=131)
Any Grade (%) Grade ≥ 3 (%)
Any Grade (%) Grade ≥ 3 (%)
Hypertension
67.8
41.8
9.2
2.3
Diarrhea
59.4
8
8.4
0
Decreased appetite
50.2
5.4
11.5
0
Decreased weight
46.4
9.6
9.2
0
Nausea
41.0
2.3
13.7
0.8
Fatigue
39.5
4.6
19.1
0.8
Stomatitis
35.6
4.2
3.8
0
Palmar-plantar erthrodysesthesia
syndrome
31.8
3.4
0.8
0
Proteinuria
31.0
10
1.5
0
Vomiting
28.4
1.9
6.1
0
Headache
27.6
2.7
6.1
0
Schlumberger M, et al. N Engl J Med 2015;372:621-30. DOI: 10.1056/NEJMoa1406470