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MECANISMO ACCIÓN LENVATINIB
BRAF
CRAF
RAS
MEK
ERK
mTOR
PI3K
TSC2
ATK
Nucleus
Cytoplasm
Gene expression
Cell proliferation
Differentiation
Apoptosis
Growth Factor Receptors
(VEGFR, FGFR, PDGFR, RET)
Growth Factors
(VEGF, FGF, PDGF, GDNF)
S6K
PTEN
Angiogenesis
Survival
Tumour Cell
Tumour Endothelial Cell or Pericyte
FGFR
VEGFR
PDGFR
FGF
VEGF
PDGF
HIF
RAS
MEK
ERK
Apoptosis
Nucleus
Gene expression
Cytoplasm
RAF
mTOR
PI3K
ATK
S6K
PTEN
Angiogenesis
•
Differentiation
•
Proliferation
•
Migration
•
Tubule formation
Lenvatinib
Lenvatinib