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•
Whole genome
•
Whole exome
•
Whole transcriptome
Pan Genomic
Analysis
•
Single gene assays
•
Low multiplex
•
NGS panels
•
Hybrid capture
•
Amplicon capture
Targeted
Assays
Clinical Labs
• Higher coverage of genomic regions of interest
• Lower cost and time
• Enrichment methods to improve detection
• Provide results in clinical time frame
Primarily research labs
• Unbiased approach – comprehensive
• Higher cost limits sequencing depth
• Longer turnaround time (TAT) – usually not suitable for
therapeutic decisions in most clinical lung cancer
settings
Marc Ladanyi, M.D, WCLC 2017
Molecular Assays for Genomic Characterization