Biomarcadores de respuesta a la inmunoterapia y a otros tratamientos en la práctica clínica asistencial: Retos y perspectivas de futuro

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Illumina HiSeq
Hybridization Capture
Amplicon Capture
Illumina MiSeq
10 – 100s of genes
Advantage: lowest input DNA
requirement
Disadvantages: poorly suited to
detection of copy number changes and
rearrangements
100s to 20,000 genes
Advantage: better suited to detection of
copy number changes and
rearrangements , more sensitive
Disadvantages: higher input DNA
requirement
Ion Torrent PGM
Illumina NextSeq
Next Generation Sequencing Platforms
Marc Ladanyi, M.D, WCLC 2017