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Better

Worse

7 9

5

3

0

15 17

21

19

23 25 27 29 31 33

2 4 6 8

11 13

10 12

1

0.4

0.2

0.0

-0.2

-0.4

0.6

FACT-P total score

ADT + Placebos

ADT + AA + P

Cycle*

338

309

250

192

202

119

135

77

65

33

20

7

0

0

ADT + Placebos, 8.3 mo

Patients without degradation

in FACT-P total score (%)

100

80

60

20

0

40

597

602

0

6

12

18

24

30

36

42

Months

ADT + AA + P, 12.9 mo

HR 0.85 (95% CI, 0.74-0.99)

P

= 0.0322

Patients at risk

ADT + AA + P

ADT + Placebos

ADT + AA + P mejora significativa QoL

HRQoL per FACT-P

15% Risk Reduction

for HRQoL Degradation

Mean Change From Baseline

Differed from Cycle 5 Onward

*1 cycle = 28 days.

Chi K, ESMO 2017