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37% Risk Reduction

for Worst Pain Progression

13

10

8

6

1 2 4

7

Mean change from baseline

in worst pain score (BPI-SF)

0.6

0.4

0.2

0.0

-0.2

-0.4

0

3 5

9

12

ADT + Placebos

ADT + AA + P

15 17

21

19

23 25

Cycle*

27 29 31 33

11

Worse

Better

597

602

456

387

356

246

299

162

218

99

115

44

47

10

2

1

0

Months

6

ADT + Placebos, NR

ADT + AA + P, NR

12

18

24

30

36

42

Patients without worst pain

progression (%)

HR 0.63 (95% CI, 0.52-0.77)

P

< 0.0001

100

80

60

20

0

40

Patients at risk

ADT + AA + P

ADT + Placebos

*1 cycle = 28 days.

ADT + AA + P mejora significativa dolor

Mean Change From Baseline

Differed From Cycle 2 Onward

Chi K, ESMO 2017