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NATURAL HISTORY
Localised disease
Local and/or
biochemical relapse
Metastatic disease
Castration Resistant M1
Death by
Prostate Cancer
Curative treatment
Local salvage treatment
or hormonal treatment
Castration resistant
M0
OTHER CAUSES OF DEATH
90%
ADT, chemotherapy, AR_signalling inhibitors,
Radium-223, (PARPi)…