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AR signalling is attenuated in CRPC-NE
(broad spectrum)
Genomic overlap
CRPC-Adeno and CRPC-NE
Marked epigenetic differences
CRPC-Adeno and CRC-NE
H. Beltran et al, Nat Med, 2016
Models of evolution that may occur during PrCa progression towards the Neuroendocrine phenotype
NEUROENDOCRINE transformation of CRPC in response to AR singnalling inhibitors