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Enzalutamide at ADT progression reduced the risk of

disease progression by 56% versus bicalutamide

Bicalutamide

Enzalutamide

HR=0.44

(95% CI: 0.34–0.57)

p=0.0001

56%

RISK REDUCTION

100

0

33

30

27

21

24

18

15

12

9

6

3

0

50

Months

PFS (%)

Enzalutamide, n

184

159

131

107

86

71

52

33

21

13

8

5

Bicalutamide, n

191

133

85

61

44

30

13

7

4

2

2

1

Shore ND, et al. Lancet Oncol 2016