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Recognition of tumor by T cell through
MHC/antigen/TCR interaction mediates IFN-γ release
and PD-L1/2 up-regulation on tumor
Priming and activation of T cells through
MHC/antigen/TCR and CD28/B7 interactions
with antigen-presenting cells
Nivolumab
MHC
PD-L1 PD-1
PD-1
T-cell
receptor
T-cell
receptor
PD-L1
PD-L2
CD28
T cell
NFκB
Other
PI3K
Tumor
cell
IFNγR
Shp-2
Shp-2
Antigen
Antigen
MHC
B7
PD-1
PD-1
Nivolumab blocks the PD-1 receptor
PD-L2
IFNγ
Adapted from Pardoll DM et al.
Nat Rev Cancer
2012.
1
Dendritic
cell