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CRYSTAL

HR: 0,79 (p<0,05

)

2000

2008

2013

2017

HR

0,1

0,5

1

EPIC

HR: 0,95 (ns)

CRYSTAL

HR: 0,93 (ns)

CO.17

HR: 0,77 (p<0,05)

BOND-1

HR: 0,91 (ns)

CO.17

HR: 0,55 (p<0,05)

CRYSTAL

(

Eric Van Cutsem. JCO, 2011

)

FOLFIRI+Cetuximab vs FOLFIRI

N: 1198 (1:1)

1063 (88.7%) 666 K-ras wild-type. 397 K-ras mutant.

1ary end-point: TTP

Results:

- TTP HR 0,69 (p<0,05) 9,9 m vs 8,4 m

- OS HR 0,796 (p<0,05) 23,5 m vs 20 m

- RR 56,3% vs 39,7% (p<0,05)