13 / 18
NIVO+IPI
(n = 43)
NIVO
(n = 58)
IPI
(n = 31)
Median PFS, months (95% CI)
2.6 (1.7, 2.9)
2.1 (1.9, 2.6)
2.3 (1.7, 2.6)
HR (95% CI)
NIVO+IPI over NIVO or
IPI
–
0.7 (0.5, 1.1)
0.5 (0.3, 0.9)
43
14
12
0
11
8
8
6
1
0
NIVO+IPI
Time (Months)
PFS (%)
100
90
80
70
60
50
40
30
20
0
10
3
6
27
9
12
15
18
21
24
0
Number of Patients at Risk
58
13
9
0
5
5
5
5
4
2
NIVO
31
2
0
0
0
0
0
0
0
0
IPI
10%
17%
10%
20%
18%
29%
NIVO+IPI
NIVO
IPI
SLP en pacientes con LDH > 2 x LSN
J Larkin SMR 2016