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P

=.045*

40

P

=.047*

P

<.001*

30

20

10

0

bFGF

(pg/mL)

40

P

<.001*

P

<.01*

30

20

ULN

0

PIGF

(pg/mL)

P

<.001*

1,000

P

<.001*

800

400

ULN

0

HGF

(pg/mL)

P

=.046*

200

600

600

P

=.001*

P

<.001*

500

300

100

0

MMP-9

(ng/mL)

ULN

400

P

<.001*

12,000

P

=.02*

11,000

10,000 ULN

0

VEGFR2

(pg/mL)

P

<.001*

9,000

P

=.02*

1,300

P

=.001*

1,250

750

ULN

0

PDGF

(pg/mL)

P

=.02*

250

1,000

500

bevacizumab+FOLFIRI (1L)