P
=.045*
40
P
=.047*
P
<.001*
30
20
10
0
bFGF
(pg/mL)
40
P
<.001*
P
<.01*
30
20
ULN
0
PIGF
(pg/mL)
P
<.001*
1,000
P
<.001*
800
400
ULN
0
HGF
(pg/mL)
P
=.046*
200
600
600
P
=.001*
P
<.001*
500
300
100
0
MMP-9
(ng/mL)
ULN
400
P
<.001*
12,000
P
=.02*
11,000
10,000 ULN
0
VEGFR2
(pg/mL)
P
<.001*
9,000
P
=.02*
1,300
P
=.001*
1,250
750
ULN
0
PDGF
(pg/mL)
P
=.02*
250
1,000
500
bevacizumab+FOLFIRI (1L)