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La población del estudio traslacional (n=482) es

representativa de la población ITT (n=1226)

Biomarker population representative of ITT population (based

on OS curves)

Similar HR

Similar shape of the curves incl. long-term

Similar demographics except fewer samples from patients in

the Americas

Evaluable population for

biomarkers

ITT population

Placebo/ Folfiri

(N=265)

Aflibercept/ Folfiri

(N=288)

Placebo/ Folfiri

(N=614)

Aflibercept/ Folfiri

(N=612)

Prior bevacizumab [n

(%)]

Number

265

288

614

612

Yes

79 (29.8%)

90 (31.3%)

187 (30.5%)

186 (30.4%)

No

186 (70.2%)

198 (68.8%)

427 (69.5%)

426 (69.6%)

ITT

Biomarker Population

HR = 0.817 (0.713-0.937)

P = 0.0032

HR = 0.804 (0.656-0.985)

P = 0.03

There is no formal test to compare the biomarker and ITT populations; populations were assessed by

comparing the shape of the curves, the HRs, and the patient characteristics.

Tejpar, S. et al VELOUR trial biomarkers update: Impact of RAS, BRAF and sidedness on aflibercept activity

WCGIC 2017, Barcelona, Spain