Tratamiento Dirigido en el Cáncer de Pulmón Microcítico: El Papel de los Marcadores

Epigenetics, EZH2 and SCLC

Poirier et al., Oncogene 2015

•

Capable of

methylating residues of histones and CpG islan-containing

promoters

: essential for

cell cycle progression

•

EZH2 places the repressive

chromatin

H3K27

me3

modification

•

Associated with

gene silencing