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Optimal First-Line Therapy for Advanced

ALK+ NSCLC

Crizotinib

Profile 1014

Ceritinib

ASCEND-3

1L

2L

11 months

18 months

(combined PFS)

Brigatinib

Ph 1-2

Alectinib

NP28673

Crizotinib

Profile 1014

Crizotinib

Profile 1014

24 months

(combined PFS)

21months

(combined PFS)

11 months

11 months