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Nuevo algoritmo terapéutico en el CPNM
EGFR con T790M+ a la progresión
T790M
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In 50-60% of AR cases
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Substitution of threonine to methionine at amino-acid position 790 in exon 20 of EGFR gene
enhances the ATP affinity of the kinase domain of the EGFR-mutant receptor restoring its
affinity for ATP to that of wt
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Minor clones with T790M+ with low allelic frequencies identified in treatment-naïve tumors
Pressure from TKIs may select for enriched growth of these T790M clones, leading to AR