4 / 31
doi:10.1038/nature11412
Comprehensive molecular portraits of human breast tumors
The Cancer Genome Atlas Network
Gen
Mutado
TP53
187 (37%)
PIK3CA
180 (36%)
GATA3
54 (11%)
MAP3K1
39 (8%)
MLL3
37 (7%)
CDH1
33 (6.5%)
MAP2K4
21 (4%)
RUNX1
18 (3.5%)
PTEN
17 (3.4%)
TBX3
13 (2.5%)
Integration of information across 5 platforms confirmed
the existence of 4 main breast cancer classes