23 / 28
Gene
PROREPAIR
N=419
%
Pritchard et al
N=692
%
ATM
8
1.9
11
1.6
ATR
0
0
2
0.3
BAP1
0
0
0
0
BARD1
0
0
0
0
BRCA1
4
0.9
6
0.9
BRCA2
14
3.3
37
5.3
BRIP1
0
0
1
0.14
CHEK2
2
0.5
10
1.4
FAM175A
0
0
1
0.14
GEN1
0
0
2
0.3
MLH1
0
0
0
0
MRE11A
2
0.5
1
0.14
MSH2
1
0.2
1
0.14
MSH6
0
0
1
0.14
NBN
0
0
2
0.3
PALB2
0
0
3
0.4
PMS2
0
0
2
0.3
RAD51C
0
0
1
0.14
RAD51D
0
0
3
0.4
XRCC2
0
0
0
0
1 in 7
mCRPC patients harbour a gDDR
mutation
Prevalence may vary accross
populations
BRCA2
is the most prevalent