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Enzalutamide at ADT progression reduced the risk of

radiographic progression versus bicalutamide

Bicalutamide

Enzalutamide

HR=0.51

(95% CI: 0.36–0.74)

p=0.0002

49%

RISK REDUCTION

100

0

33

30

27

21

24

18

15

12

9

6

3

0

50

Months

rPFS (%)

Enzalutamide, n

184

147

120

99

82

65

49

33

20

13

8

5

Bicalutamide, n

191

104

73

51

38

30

14

7

3

2

2

1

Shore ND, et al. Lancet Oncol 2016