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Hypothetical representation of patterns of response to

1st line treatment

Grande E, et al.

World J Clin Oncol

2017;8(2):100–5

3

6

9

12

15

Time (months)

Volume of disease

Primary refractory

early progressors

High TGR

Intermediate

progressors

Intermediate TGR

Very slow progressors

Low TGR

Late progressors

Intermediate/high TGR