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Treatment options in 2

nd

-3

rd

line

AXITINIB

NIVOLUMAB

CABOZANTINIB

LENVATINIB +

EVEROLIMUS

Choueiri et al Lancet Oncol 2016

ECOG 0: 69% (IK 70%)

Prior Sunitinib: 61%

Poor Risk MSKCC: 14%