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Not all mCRC patients receive treatment beyond 1

st

line

1

1

st

-line agents may have potential to modify tumour biology and/or

sensitise/desensitise the tumour to later treatment lines

2,3

100

53

28

13

0

10

20

30

40

50

60

70

80

90

100

1st line

2nd line

3rd line

4th line

Proportion of patients (%)

The importance of 1

st

-line treatment choice in mCRC

1. Abrams TA, et al. J Natl Cancer Inst 2014. 2. Modest DP, et al. J Clin Oncol 2015. 3. Wainberg ZA, Drakaki A. Expert Opin Biol Ther 2015..

N = 4877

1

st

line

2

n

line

3

r

line

4

th

line